Cat Travel

Whats the best way to travel with a cat?

My friend is moving to GA & it is an 8 hour car trip and she has to take her cat. Im movin in a couple of months and have an even longer way to take mine. My cat travels well, but hers does not. Whats the best way to make the trip easier on our kitties? The less they stress out the better it is for everyone. Any helpfull tricks or ideas would be really great!

I traveled by plane with my cat when he was younger, I wrote my experiences on a website. Many tips will apply, but in a car of course you can use a larger carrier because it doesn't have to fit under the seat and all... give him room to stand up and turn around comfortably.
I would not tranquilize a cat unless he's very nervous; it can cause complications and even makes some cats more nervous. If your friend feels she needs to, use something like Rescue Remedy rather than a strong tranquilizer.